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Reference: Wickner RB, et al. (2011) Prion diseases of yeast: amyloid structure and biology. Semin Cell Dev Biol 22(5):469-75

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Abstract

Prion "variants" or "strains" are prions with the identical protein sequence, but different characteristics of the prion infection: e.g. different incubation periods for scrapie strains or different phenotype intensities for yeast prion variants. We have shown that infectious amyloids of the yeast prions [PSI+], [URE3] and [PIN+] each have an in-register parallel ?-sheet architecture. Moreover, we have pointed out that this amyloid architecture can explain how one protein can faithfully transmit any of several conformations to new protein monomers. This explains how proteins can be genes.

Reference Type
Journal Article | Review | Research Support, N.I.H., Intramural
Authors
Wickner RB, Edskes HK, Kryndushkin D, McGlinchey R, Bateman D, Kelly A
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