We have known for decades that vertebrate kinetochores can nucleate microtubules. However, the role of such microtubules was unclear. Kitamura et al. investigated this issue by following a marked budding yeast centromere after its conditional reactivation to examine microtubule capture at unattached kinetochores. They found not only that yeast kinetochores can nucleate microtubules, but also that such microtubules facilitate attachment by decreasing the time required for spindle-pole-associated microtubules to make contact with unattached kinetochores. Historically, the fact that microtubules nucleated at kinetochores are opposite in polarity to those in mature spindle fibers was used to argue that they were not physiologically relevant for spindle assembly. Kitamura et al. have now shown that they, in fact, do play a role, and then rapidly depolymerize after spindle fiber attachments form. In sum, this paper provides a function for a previously mysterious microtubule population and outlines a surprising and dynamic mechanism through which kinetochore-originated microtubules assist spindle pole microtubules to efficiently "locate" unattached kinetochores. It also shows how this assistance mechanism is shut off to dim the "locator beacon" after correct attachments have been made. UNDERSTANDING KINETOCHORE-NUCLEATED MICROTUBULES:CI - Copyright (c) 2011 Elsevier Inc. All rights reserved.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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