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Reference: Rives AW and Galitski T (2003) Modular organization of cellular networks. Proc Natl Acad Sci U S A 100(3):1128-33

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Abstract

We investigated the organization of interacting proteins and protein complexes into networks of modules. A network-clustering method was developed to identify modules. This method of network-structure determination was validated by clustering known signaling-protein modules and by identifying module rudiments in exclusively high-throughput protein-interaction data with high error frequencies and low coverage. The signaling network controlling the yeast developmental transition to a filamentous form was clustered. Abstraction of a modular network-structure model identified module-organizer proteins and module-connector proteins. The functions of these proteins suggest that they are important for module function and intermodule communication.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Rives AW, Galitski T
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