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Reference: Laxman S and Tu BP (2010) Systems approaches for the study of metabolic cycles in yeast. Curr Opin Genet Dev 20(6):599-604

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Abstract


Over four decades ago, the first oscillations in metabolism in yeast cells were reported. Since then, multiple forms of oscillatory behavior have been observed in yeast grown under a variety of continuous culturing environments. The remarkable synchrony of cells undergoing such oscillations has made them ideal subjects for investigation using systems-based approaches. Herein, we briefly summarize previous work on the characterization of such oscillations using systems approaches, and present the long-period, Yeast Metabolic Cycle as an excellent model system for deciphering the temporal organization of fundamental cellular and metabolic processes at unprecedented resolution.CI - Copyright (c) 2010 Elsevier Ltd. All rights reserved.

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Journal Article
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Laxman S, Tu BP
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