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Reference: Evangelisti AM and Conant GC (2010) Nonrandom Survival of Gene Conversions among Yeast Ribosomal Proteins Duplicated through Genome Doubling. Genome Biol Evol 2:826-834

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Abstract


By comparing the patterns of evolution in the coding and upstream non-coding regions of yeast ribosomal proteins duplicated in a genome duplication, we find that while nonsynonymous sites in the coding sequences show strong evidence for the fixation of recent gene conversion events, similar patterns are less evident among the synonymous positions and non-coding regulatory elements. This result suggests a potential explanation for the somewhat puzzling fact that duplicated ribosomal protein genes are not functionally redundant despite their very high protein sequence identity. An analysis of the patterns of regulatory network evolution after genome duplication also indicates that the duplicated proteins have diverged considerably in expression despite their similar protein sequences.

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Journal Article
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Evangelisti AM, Conant GC
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