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Reference: Lee KM and O'Connell MJ (2006) A new SUMO ligase in the DNA damage response. DNA Repair (Amst) 5(1):138-41

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Abstract

SUMO is a small ubiquitin-like protein that is attached to target proteins, altering their localization and function. The condensin and cohesin-related Smc5/6 complex has been linked to DNA repair and checkpoint responses, but details of its molecular function have remained obscure. Recent reports show one subunit of the complex is a SUMO ligase, providing another link between protein sumoylation and DNA damage responses.

Reference Type
Journal Article | Review | Research Support, Non-U.S. Gov't | Research Support, N.I.H., Extramural
Authors
Lee KM, O'Connell MJ
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