Reference: Takata K and Wood RD (2009) Bypass specialists operate together. EMBO J 28(4):313-4

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Abstract


New experiments show that different combinations of translesion DNA polymerases act to bypass lesions in mammalian cells, depending on the type of DNA damage. Bypass of most lesions tested was dependent on REV3L (pol zeta) and at least one additional DNA polymerase. The data fit a model whereby DNA polymerases work sequentially to bypass adducts in DNA.

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Takata K, Wood RD
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