Reference: Stefan Dimmer K and Rapaport D (2010) The enigmatic role of Mim1 in mitochondrial biogenesis. Eur J Cell Biol 89(2-3):212-5

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Abstract


The translocase of the outer mitochondrial membrane (TOM complex) is a multi-subunit complex that serves as the general entry site for newly synthesized proteins into the organelle. The assembly of this complex is a multi-step process that requires the coordinated action of several proteins. A central, but rather undefined role in this process is played by Mim1, a mitochondrial outer membrane protein. The deletion of MIM1 leads to severe defects in the biogenesis of TOM complex subunits and to altered mitochondrial morphology. The protein is built from an N-terminal cytosolic domain, a central transmembrane segment, and a C-terminal domain facing the intermembrane space. In this review we summarize our current knowledge on the structure-function relationship of Mim1 and discuss some possibilities for its molecular function.CI - Copyright 2009 Elsevier GmbH. All rights reserved.

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Journal Article | Review | Research Support, Non-U.S. Gov't
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Stefan Dimmer K, Rapaport D
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