Reference: Brahemi G, et al. (2010) Homology Modelling of Human E1 Ubiquitin Activating Enzyme. Lett Drug Des Discov 7(1):57-62

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Abstract


Human E1 is a key player in protein ubiquitination, however the E1 structure is not available. In this paper, we describe the derivation of a human E1 structure using molecular modelling based on the crystal structure of S. cerevisiae E1 and M. Musculus E1. Key interactions between our E1 model and ubiquitin are also discussed.

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Journal Article
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Brahemi G, Burger AM, Westwell AD, Brancale A
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