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Reference: Li M, et al. (2010) Identifying the overlapping complexes in protein interaction networks. Int J Data Min Bioinform 4(1):91-108

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Abstract

Identification of protein complexes in large interaction networks is crucial to understanding principles of cellular organisation and predict protein functions. In this paper, a new algorithm of Identifying Protein Complexes based on Maximal Clique Extension (IPC-MCE) is proposed. The maximal clique is considered as the core of the protein complex. Proteins in a complex are classed into core vertices and peripheral vertices. The relation between the core vertices and peripheral vertices is measured by the Interaction Probability. The algorithm IPC-MCE is applied to the protein interaction network of Saccharomyces cerevisiae. Many well-known protein complexes are detected.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Li M, Wang J, Chen J, Cai Z, Chen G
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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

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