Take our Survey

Reference: Bleackley MR, et al. (2009) Blood iron homeostasis: newly discovered proteins and iron imbalance. Transfus Med Rev 23(2):103-23

Reference Help

Abstract


In biological systems, iron exerts 2 contrasting effects. The chemical reactivity of iron is essential for the biological activities of proteins such as hemoglobin, ribonucleotide reductase, the cytochromes, and aconitases. However, free iron in a cell has the propensity to generate free radicals which can damage cellular components containing proteins, lipids, and nucleic acids. To maintain the balance between iron as an essential nutrient and iron as a potential cytotoxin, a number of biological protective mechanisms have evolved. As shown in the thalassemias, iron imbalance can have devastating effects on human health. Recently, several new proteins have been described that play critical roles in iron regulation including the master regulator of iron metabolism (hepcidin). In this review, we discuss the new knowledge that has arisen from studies in yeast and in humans, and we show how these studies are shedding new light on some well-known human disorders.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Bleackley MR, Wong AY, Hudson DM, Wu CH, MacGillivray RT
Primary Lit For
Additional Lit For
Review For

Interaction Annotations


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

Phenotype Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

Regulation Annotations


Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine.

Regulator Target Experiment Assay Construct Conditions Strain Background Reference