Reference: Polo S and Di Fiore PP (2008) Finding the right partner: science or ART? Cell 135(4):590-2

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Abstract


In response to environmental cues, certain plasma membrane proteins are ubiquitinated, signaling their endocytosis and degradation. In the budding yeast, a single enzyme, Rsp5, is charged with this task. Lin et al. (2008) now identify an arrestin-related family of Rsp5 adaptor proteins called ARTs that confer specificity on the ubiquitination of plasma membrane proteins and contribute to the maintenance of the correct cell surface protein repertoire.

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Comment | Journal Article | Research Support, Non-U.S. Gov't
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Polo S, Di Fiore PP
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