Reference: Passarella S, et al. (2008) Mitochondria and l-lactate metabolism. FEBS Lett 582(25-26):3569-76

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Abstract

Although mitochondria have been the object of intensive study over many decades, some aspects of their metabolism remain to be fully elucidated, including the l-lactate metabolism. We review here the novel insights arisen from investigations on l-lactate metabolism in mammalian, plant and yeast mitochondria. The presence of l-lactate dehydrogenases inside mitochondria, where l-lactate enters in a carrier-mediated fashion, suggests that mitochondria play an important role in l-lactate metabolism. Functional studies have demonstrated the occurrence of several l-lactate carriers. Moreover, immunological investigations have proven the existence of monocarboxylate translocator isoforms in mitochondria.

Reference Type
Journal Article
Authors
Passarella S, Bari LD, Valenti D, Pizzuto R, Paventi G, Atlante A
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