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Reference: Arnett DR, et al. (2008) A proteomics analysis of yeast Mot1p protein-protein associations: insights into mechanism. Mol Cell Proteomics 7(11):2090-106

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Abstract


Yeast Mot1p, a member of the Snf2-ATPase family of proteins, is a transcriptional regulator that has the unusual ability to both repress and activate mRNA gene transcription. In order to identify interactions with other proteins that may assist Mot1p in its regulatory processes, Mot1p was purified from replicate yeast cell extracts and Mot1p-associated proteins identified by coupled multidimensional liquid chromatography and tandem mass spectrometry. Using this approach we have generated a catalog of Mot1p interacting proteins. Mot1p interacts with a range of transcriptional coregulators, as well as proteins involved in chromatin remodeling. We propose that interaction with such a wide range of proteins may be one mechanism through which Mot1p subserves its roles as a transcriptional activator and repressor.

Reference Type
Journal Article
Authors
Arnett DR, Jennings JL, Tabb DL, Link AJ, Weil PA
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Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

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