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Reference: Han Q, et al. (2008) Gcn5- and Elp3-induced histone H3 acetylation regulates hsp70 gene transcription in yeast. Biochem J 409(3):779-88

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Abstract


This study intended to elucidate the mechanisms by which histone acetylation participates in transcriptional regulation of hsp70 genes SSA3 and SSA4 in yeast. Our results indicated that histone acetylation was required for transcriptional activation of SSA3 and SSA4 genes. The histone acetyltransferases (HATs) Gcn5 and Elp3 modulated the hsp70 gene transcription by affecting the acetylation status of histone H3. Although the two HATs had an overlapping function of acetylating histone H3, they affected hsp70 genes transcription through different ways. The recruitment of Gcn5 was Swi/Snf-dependent and it was required for HSF binding and affected RNAP II recruitment, whereas Elp3 exerted its roles mainly through affecting RNAP II elongation. These data provide insights into the effects of Gcn5 and Elp3 in hsp70 gene transcription and underscore the importance of the histone acetylation for transcriptional initiation and elongation in hsp genes.

Reference Type
Journal Article
Authors
Han Q, Lu J, Duan J, Su D, Hou X, Li F, Wang X, Huang B
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