Reference: Kolter T (2007) The fatty acid factory of yeasts. Angew Chem Int Ed Engl 46(36):6772-5

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Abstract


Fatty acids are essential metabolites for nearly all organisms. Yeasts, fungi, and animals synthesize them using fatty acid synthases of type I (FAS I) in the cytoplasm, whereby the FAS I of animals is distinct from that of fungi and yeasts. Recently obtained high-resolution X-ray structures of the 2.6-MDa FAS enzyme from yeast and fungi (see picture) now allow a closer look at the mechanism of this reaction.

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Kolter T
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