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Reference: Sclafani RA and Holzen TM (2007) Cell cycle regulation of DNA replication. Annu Rev Genet 41:237-80

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Abstract

Eukaryotic DNA replication is regulated to ensure all chromosomes replicate once and only once per cell cycle. Replication begins at many origins scattered along each chromosome. Except for budding yeast, origins are not defined DNA sequences and probably are inherited by epigenetic mechanisms. Initiation at origins occurs throughout the S phase according to a temporal program that is important in regulating gene expression during development. Most replication proteins are conserved in evolution in eukaryotes and archaea, but not in bacteria. However, the mechanism of initiation is conserved and consists of origin recognition, assembly of prereplication (pre-RC) initiative complexes, helicase activation and replisome loading. Cell cycle regulation by protein phosphorylation ensures that pre-RC assembly can only occur in G1 phase, while helicase activation and loading can only occur in S phase. Checkpoint regulation maintains high fidelity by stabilizing replication forks and preventing cell cycle progression during replication stress or damage. Expected final online publication date for the Annual Review of Genetics Volume 41 is November 10, 2007. Please see http://www.annualreviews.org/catalog/pubdates.aspx for revised estimates.

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Journal Article
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Sclafani RA, Holzen TM
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