Reference: Lykke-Andersen S and Jensen TH (2007) Overlapping pathways dictate termination of RNA polymerase II transcription. Biochimie 89(10):1177-82

Reference Help

Abstract


While it has long been appreciated that regulation of transcription initiation is vital to sustain dynamic gene expression, recent findings suggest that the control of transcription termination is equally important. Besides serving to avoid interference with downstream genes, transcription termination is a crucial determinant for the fate of the newly synthesized transcript through its intimate coupling to RNA 3'-end formation. This makes termination of eukaryotic RNA polymerase II transcription an interesting case since this enzyme is capable of generating very heterogenous transcripts ranging from protein coding mRNAs over small and stable non-coding RNAs to so-called cryptic unstable transcripts. Recent discoveries in the yeast S. cerevisiae have established that 3'-end formation of these functionally distinct molecules is carried out by a set of both shared and specific transcription termination and 3'-end processing factors that concurrently travel along with the transcribing polymerase. The choice of termination mode depends on sequences in the transcribed RNA, as well as on the distance of the termination signal to the promoter. The apparent ability of RNA polymerase II to switch between termination systems suggests hitherto unappreciated commonalities between the biosynthesis pathways of protein coding and non-coding transcripts.

Reference Type
Journal Article
Authors
Lykke-Andersen S, Jensen TH
Primary Lit For
Additional Lit For
Review For

Interaction Annotations


Increase the total number of rows showing on this page by using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details about experiment type and any other genes involved in the interaction.

Interactor Interactor Type Assay Annotation Action Modification Phenotype Source Reference

Gene Ontology Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table.

Gene Gene Ontology Term Qualifier Aspect Method Evidence Source Assigned On Annotation Extension Reference

Phenotype Annotations


Increase the total number of rows showing on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; filter the table using the "Filter" box at the top of the table; click on the small "i" buttons located within a cell for an annotation to view further details.

Gene Phenotype Experiment Type Mutant Information Strain Background Chemical Details Reference

Regulation Annotations


Increase the total number of rows displayed on this page using the pull-down located below the table, or use the page scroll at the table's top right to browse through the table's pages; use the arrows to the right of a column header to sort by that column; to filter the table by a specific experiment type, type a keyword into the Filter box (for example, “microarray”); download this table as a .txt file using the Download button or click Analyze to further view and analyze the list of target genes using GO Term Finder, GO Slim Mapper, SPELL, or YeastMine.

Regulator Target Experiment Assay Construct Conditions Strain Background Reference