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Reference: Cortes-Ledesma F, et al. (2007) SMC proteins, new players in the maintenance of genomic stability. Cell Cycle 6(8):914-8

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Abstract

Homologous recombination (HR) is one of the key mechanisms responsible for the repair of DNA double-strand breaks (DSBs), including those that occur during DNA replication. Recent studies in yeast and mammals have uncovered that the SMC complexes cohesins and Smc5-Smc6 are recruited to induced DSBs, and play a role in the maintenance of genome stability by favouring SCR as the main recombinational DSB repair mechanism. These new results raise intriguing questions such as whether SMC proteins might play a functional role at collapsed replication forks, which may represent the main source of spontaneous recombinogenic damage. A deeper knowledge of the role of SMC proteins in DSB repair should contribute to a better understanding of chromosome dynamics and stability.

Reference Type
Journal Article
Authors
Cortes-Ledesma F, De Piccoli G, Haber JE, Aragon L, Aguilera A
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