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Reference: Kikuchi Y, et al. (2007) Involvement of Rho-type GTPase in control of cell size in Saccharomyces cerevisiae. FEMS Yeast Res 7(4):569-78

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Abstract

Maintaining specific cell size, which is important for many organisms, is achieved by coordinating cell growth and cell division. In the budding yeast Saccharomyces cerevisiae, the existence of two cell-size checkpoints is proposed: at the first checkpoint, cell size is monitored before budding at the G(1)/S transition, and at the second checkpoint, actin depolymerization occurring in the small bud is monitored before the G(2)/M transition. Morphological analyses have revealed that the small GTPase Rho1p participates in cell-size control at both the G(1)/S and the G(2)/M boundaries. One group of rho1 mutants (rho1A) underwent premature entry into mitosis, leading to the birth of abnormally small cells. In another group of rho1 mutants (rho1B), the mother cells failed to reach an appropriate size before budding, and expression of the G(1) cyclin Cln2p began at an earlier phase of the cell cycle. Analyses of mutants defective in Rho1p effector proteins indicate that Skn7p, Fks1p and Mpk1p are involved in cell-size control. Thus, Rho1p and its downstream regulatory pathways are involved in controlling cell size in S. cerevisiae.

Reference Type
Journal Article
Authors
Kikuchi Y, Mizuuchi E, Nogami S, Morishita S, Ohya Y
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