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Reference: Slessareva JE and Dohlman HG (2006) G protein signaling in yeast: new components, new connections, new compartments. Science 314(5804):1412-3

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Abstract

Signaling by cell surface receptors and heterotrimeric guanine nucleotide-binding proteins (G proteins) is one of the most exhaustively studied processes in the cell but remains a major focus of molecular pharmacology research. The pheromone-response system in yeast (see the Connections Map at Science's Signal Transduction Knowledge Environment) has provided numerous major advances in our understanding of G protein signaling and regulation. However, the basic features of this prototypical pathway have remained largely unchanged since the mid-1990s. New tools available in yeast are beginning to uncover new pathway components and interactions and have revealed signaling in unexpected locations within the cell.

Reference Type
Journal Article | Research Support, N.I.H., Extramural
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Slessareva JE, Dohlman HG
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