Reference: Wagner A (2002) Asymmetric functional divergence of duplicate genes in yeast. Mol Biol Evol 19(10):1760-8

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Abstract


Most duplicate genes are eliminated from a genome shortly after duplication, but those that remain are an important source of biochemical diversity. Here, I present evidence from genome-scale protein-protein interaction data, microarray expression data, and large-scale gene knockout data that this diversification is often asymmetrical: one duplicate usually shows significantly more molecular or genetic interactions than the other. I propose a model that can explain this divergence pattern if asymmetrically diverging duplicate gene pairs show increased robustness to deleterious mutations.

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Journal Article | Research Support, U.S. Gov't, P.H.S.
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Wagner A
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