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Reference: Lebreton A, et al. (2006) A functional network involved in the recycling of nucleocytoplasmic pre-60S factors. J Cell Biol 173(3):349-60

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Abstract


Eukaryotic pre-ribosomes go through cytoplasmic maturation steps before entering translation. The nucleocytoplasmic proteins participating in these late stages of maturation are reimported to the nucleus. In this study, we describe a functional network focused on Rei1/Ybr267w, a strictly cytoplasmic pre-60S factor indirectly involved in nuclear 27S pre-ribosomal RNA processing. In the absence of Rei1, the nuclear import of at least three other pre-60S factors is impaired. The accumulation in the cytoplasm of a small complex formed by the association of Arx1 with a novel factor, Alb1/Yjl122w, inhibits the release of the putative antiassociation factor Tif6 from the premature large ribosomal subunits and its recycling to the nucleus. We propose a model in which Rei1 is a key factor for the coordinated dissociation and recycling of the last pre-60S factors before newly synthesized large ribosomal subunits enter translation.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Lebreton A, Saveanu C, Decourty L, Rain JC, Jacquier A, Fromont-Racine M
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