BAP31 is a polytopic integral membrane protein of the endoplasmic reticulum in mammalian cells. It has been shown to participate in various cellular functions such as protein transport and apoptosis. Saccharomyces cerevisiae genome contains three open reading frames YKL065C, YMR040W and YDL072C, which encode BAP31 homologs. We named these YET1 (for Yeast ER Transmembrane protein), YET2 and YET3, respectively. Similar to mammalian BAP31, Yet1p was shown to be an integral membrane protein localized to the endoplasmic reticulum. YET genes were not essential for viability, but disruption of YET1 increased and YET3 decreased the cell growth in liquid cultures. In the yet1Δ yet3Δ and yet2Δ yet3Δ double disruptant cells the growth was restored to the level observed in the wild type cells. The results suggest that Yet proteins have partially specialized, but overlapping functions. Furthermore, yet3Δ cells showed a defect in invertase secretion. The possible role of the yeast BAP31 homologs in the ER export is discussed.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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