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Reference: Mouchel NA and Jenkins JR (2006) The identification of a functional interaction between PKC and topoisomerase II. FEBS Lett 580(1):51-7

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Abstract

Topoisomerase II plays an essential role in the segregation of chromosomes during cell division. It is also a major component of the nuclear matrix. Proteins that interact with and regulate this essential enzyme are of great interest. To investigate the role of proteins interacting with the N-terminal domain of the Saccharomyces cerevisiae topoisomerase II, we used a yeast two-hybrid protein interaction screen. We identified an interaction between the catalytic domain of the yeast protein kinase 1 enzyme (Pkc1) and the N-terminal domain of the S. cerevisiae topoisomerase II. The S. cerevisiae Pkc1 is the homologue of the mammalian calcium dependent PKC.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Mouchel NA, Jenkins JR
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