Reference: Kaplan CD and Kaplan J (2005) Regulatory oversight of the iron trade: posttranscriptional regulation in yeast. Cell Metab 2(1):4-6

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Abstract


Though a required element, iron is toxic in high concentration. New evidence reveals pathways for controlling the abundance of mRNAs encoded by iron utilization and distribution genes. These studies demonstrate sophisticated systems that limit iron uptake under conditions of abundance and lead to metabolic remodeling when iron is limited.

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Journal Article
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Kaplan CD, Kaplan J
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