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Reference: Borchsenius AS, et al. (2005) [Association between defects of karyogamy and translation termination in yeast Saccharomyces cerevisiae] Genetika 41(2):178-86

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Abstract

Mutants capable of a high frequency of cytoduction (Hfc+) were obtained in a haploid strain of Saccharomyces cerevisiae, suggesting impaired cytogamy. Nine of the 68 Hfc+ mutants showed the antisuppressor effect with respect to mutations of the SUP35 and SUP45 genes, which code for translation termination factors, or to the [PSI+] factor, which is the prion form of Sup35. Cosegregation of the characters "higher frequency of cytoduction" and "antisuppression" was demonstrated for three Hfc+ mutants. One (HFC12-2) of the Hfc+ mutations exerted a dominant antisuppressor effect with respect to [PSI+] and had no effect on [PSI+] maintenance. On the strength of the results, an interaction was assumed for translation termination components and cytoskeleton proteins, which play a role in karyogamy in yeasts.FAU - Borchsenius, A .

Reference Type
Journal Article
Authors
Borchsenius AS, Repnevskaia MV, Kurischko C, Inge-Vechtomov SG
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