Reference: Sarin S, et al. (2004) Uncovering novel cell cycle players through the inactivation of securin in budding yeast. Genetics 168(3):1763-71

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Abstract


Budding yeast securin/Pds1p, an inhibitor of the anaphase activator separase/Esp1p, is involved in several checkpoint pathways and in promoting Esp1p's nuclear localization. Using a modified synthetic genetic array (SGA) screen for genes that become essential in the absence of Pds1p, we uncovered roles for uncharacterized genes in cell cycle processes, including Esp1p activation.

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Sarin S, Ross KE, Boucher L, Green Y, Tyers M, Cohen-Fix O
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