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Reference: Luo W and Bentley D (2004) A Ribonucleolytic Rat Torpedoes RNA Polymerase II. Cell 119(7):911-4

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Abstract

Three recent papers reveal a fascinating link between pol II termination and ribonucleolytic decay of the nascent transcript by a 5'-3' exonuclease (yeast Rat1 and human Xrn2). The exonuclease travels with pol II and gains access to the nascent RNA after endonucleolytic cleavage at the poly(A) site or at a second cotranscriptional cleavage site (CoTC). It is then thought to track in a 5'-3' direction like a guided torpedo that ultimately helps dissociate the RNA polymerase elongation complex.

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Journal Article
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Luo W, Bentley D
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