Reference: Connelly JC and Leach DR (2002) Tethering on the brink: the evolutionarily conserved Mre11-Rad50 complex. Trends Biochem Sci 27(8):410-8

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Abstract


Mre11-Rad50 (MR) proteins are encoded by bacteriophage, eubacterial, archeabacterial and eukaryotic genomes, and form a complex with a remarkable protein architecture. This complex is capable of tethering the ends of DNA molecules, possesses a variety of DNA nuclease, helicase, ATPase and annealing activities, and performs a wide range of functions within cells. It is required for meiotic recombination, double-strand break repair, processing of mis-folded DNA structures and maintaining telomere length. This article reviews current knowledge of the structure and enzymatic activities of the MR complex and attempts to integrate biochemical information with the roles of the protein in a cell.

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Journal Article | Research Support, Non-U.S. Gov't | Review
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Connelly JC, Leach DR
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