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Reference: Rodriguez-Navarro S, et al. (2002) An intron in the YRA1 gene is required to control Yra1 protein expression and mRNA export in yeast. EMBO Rep 3(5):438-42

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Abstract


Yra1p is an essential and conserved mRNA export factor in yeast. Strikingly, removal of the intron from YRA1 causes a dominant-negative growth phenotype and a concomitant inhibition of mRNA export. However, both defects are neutralized by replacement of the intron of YRA1 by a different intron. Significantly, Yra1p is overproduced in yeast when expressed from its intronless gene, but Yra1p levels are the same as the wild type when expressed from an intron-containing YRA1 gene. Thus, an intron in YRA1 controls Yra1p expression and mRNA export.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Rodriguez-Navarro S, Strasser K, Hurt E
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