Reference: Souza MA, et al. (2001) New aspects of the glucose activation of the H(+)-ATPase in the yeast Saccharomyces cerevisiae. Microbiology 147(Pt 10):2849-55

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Abstract


The glucose-induced activation of plasma membrane ATPase from Saccharomyces cerevisiae was first described by Serrano in 1983. Many aspects of this signal transduction pathway are still obscure. In this paper, evidence is presented for the involvement of Snf3p as the glucose sensor related to this activation process. It is shown that, in addition to glucose detection by Snf3p, sugar transport is also necessary for activation of the ATPase. The participation of the G protein, Gpa2p, in transducing the internal signal (phosphorylated sugars) is also demonstrated. Moreover, the involvement of protein kinase C in the regulation of ATPase activity is confirmed. Finally, a model pathway is presented for sensing and transmission of the glucose activation signal of the yeast H(+)-ATPase.

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Journal Article | Research Support, Non-U.S. Gov't
Authors
Souza MA, Tropia MJ, Brandao RL
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