Silencing is a process that assembles particular regions of eukaryotic chromosomes into transcriptionally inactive chromatin structures. Silencing involves specialized regulatory sites known as silencers and a combination of general DNA-binding proteins and proteins dedicated to silencing. In the yeast Saccharomyces cerevisiae, these proteins include transcription factors and the origin recognition complex (ORC). Silencing has three recognizably separate phases: establishment, maintenance, and inheritance. At least some silencers are origins of replication, and the establishment of the silenced state requires an S phase-specific event. Once established, the silenced state is heritable, even in the absence of proteins required for its establishment. The silencing of mating-type genes bears many similarities to telomere position effects, and the two processes require many of the same proteins.
|Evidence ID||Analyze ID||Interactor||Interactor Systematic Name||Interactor||Interactor Systematic Name||Type||Assay||Annotation||Action||Modification||Phenotype||Source||Reference||Note|
|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Gene Ontology Term||Gene Ontology Term ID||Qualifier||Aspect||Method||Evidence||Source||Assigned On||Annotation Extension||Reference|
|Evidence ID||Analyze ID||Gene||Gene Systematic Name||Phenotype||Experiment Type||Experiment Type Category||Mutant Information||Strain Background||Chemical||Details||Reference|
|Evidence ID||Analyze ID||Regulator||Regulator Systematic Name||Target||Target Systematic Name||Experiment||Assay||Construct||Conditions||Strain Background||Reference|