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Reference: Richardson A, et al. (1998) The ins and outs of a molecular chaperone machine. Trends Biochem Sci 23(4):138-43

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Abstract


Genetic and biochemical work has highlighted the biological importance of the GroEL/GroES (Hsp60/Hsp10; cpn60/cpn10) chaperone machine in protein folding. GroEL's donut-shaped structure has attracted the attention of structural biologists because of its elegance as well as the secrets (substrates) it can hide. The recent determination of the GroES and GroEL/GroES structures provides a glimpse of their plasticity, revealing dramatic conformational changes that point to an elaborate mechanism, coupling ATP hydrolysis to substrate release by GroEL.

Reference Type
Journal Article | Review | Review, Tutorial
Authors
Richardson A, Landry SJ, Georgopoulos C
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