The super-suppressors in yeast are defined as allele specific suppressors which act upon mutants at two or more loci (HAWTHORNE and MORTIMER 1963). The properties of the suppressible alleles indicate that they are nonsense mutants (MANNEY 1964; HAWTHORNE and FRIIS 1964; FINK 1966), and thus the super-suppressors (nonsense suppressors) are analogous to the amber and ochre suppressors of Escherichia coli. To date, 22 different nonsense suppressors have been isolated. These suppressors can be assigned to 10 phenotypic classes on the basis of the spectra of mutant alleles suppressed. However, as many as 8 genetically distinct suppressors are found within a single phenotypic class. Thus the action spectrum alone is insufficient for the identification of a given suppressor. To facilitate the identification and description of the nonsense suppressors, the following studies were undertaken to locate the suppressor genes on the linkage map of yeast.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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