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Reference: Larimer FW, et al. (1978) Mutagenicity of methylated N-nitrosopiperidines in Saccharomyces cerevisiae. Mutat Res 57(2):155-61

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Abstract


N-Nitrosopiperidine (NP) and a number of methylated derivatives were examined for mutagenicity in Saccharomyces cerevisiae. NP, 2-methyl-NP, 3-methyl-NP, 4-methyl-NP and 3,5-dimethyl-NP were mutagens when metabolic activation (rat-liver microsomes) was provided. 2,6-Dimethyl-NP was not a mutagen. The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 leads to can1) and reversion of the his1-7 missense marker. Neither locus revertants nor suppressors of the lys1-1 ochre marker were induced, nor were revertants of the putative frameshift hom3-10.

Reference Type
Journal Article | Research Support, U.S. Gov't, Non-P.H.S.
Authors
Larimer FW, Ramey DW, Lijinsky W, Epler JL
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