Two unlinked loci controlling the glucose-repressible alcohol dehydrogenase (ADH II) in Saccharomyces cerevisiae were investigated. One locus (AD R2) was characterized by electrophoretically slow and fast alleles and by inactive adr2 mutant alleles. The ADH II pattern of heteroallelic slow X fast diploids indicates a tetrameric structure of the enzyme. AD R2 was considered as the structural gene, which codes for the ADH II subunits. Allelic adr2-f mutants could be classified by their response to the slow wild type allele (AD RS-S) in heterozygous diploids. In most cases, only the slow band appeared. In three adr2-f/ADR2-S crosses hybrid enzymes between inactive fast and active slow enzymes were formed. It was demonstrated, that allelic interactions at the protein level are not restricted to electrophoretical behaviour of hybrid enzymes. They also influence specific activities and substrate affinities. The other locus investigated, AD R1, was characterized by ADH II negative mutants (adr1) and by allelic mutants which generate only very low activity (ADR1-L). ADR1 does not influence the electrophoretic properties of slow and fast ADH II proteins. adr1 mutants have an intact structural gene, which is not expressed. The gene has probably a regulatory function with respect to ADH II synthesis.
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Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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Site | Modification | Modifier | Source | Reference |
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Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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