Reference: Baranowska H, et al. (1990) Role of the CDC8 gene in the repair of single strand breaks in DNA of the yeast Saccharomyces cerevisiae. Curr Genet 18(3):175-9

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Abstract


It has been found that the repair of single strand breaks is defective in the DNA replication mutants cdc8-1 and cdc8-3 of Saccharomyces cerevisiae both in permissive (23 degrees C) and restrictive conditions (36 degrees C). In permissive conditions we observed a significant delay in single strand break repair in a diploid strain HB7 (cdc8-1/cdc8-1), as compared with the wild-type strain. Under restrictive conditions no repair was observed, but rather degradation of MMS-damaged DNA occurred. It has been also found that the repair of single strand breaks in yeast is inhibited by cycloheximide but not by hydroxyurea.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't
Authors
Baranowska H, Zaborowska D, Jachymczyk WJ, Zuk J
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