Reference: Hougan L, et al. (1989) Cloning and characterization of the SKI3 gene of Saccharomyces cerevisiae demonstrates allelism to SKI5. Curr Genet 16(3):139-43

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Abstract


We have identified a mutant strain of the yeast Saccharomyces cerevisiae which overproduces killer toxin. This strain contains a single mutation which fails to complement defects in both the SKI3 and SKI5 genes, while a cloned copy of this gene complements both the ski3 and ski5 defects. The level of secreted toxin from a cDNA based plasmid is not increased in a ski3 strain, showing that the overproduction phenotype is dependent upon an increased level of M1 dsRNA.

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Journal Article
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Hougan L, Thomas DY, Whiteway M
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