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Reference: Weiss K and Simpson RT (1997) Cell type-specific chromatin organization of the region that governs directionality of yeast mating type switching. EMBO J 16(14):4352-60

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Abstract


Switching of mating type in Saccharomyces cerevisiae is directional; MAT alpha cells recombine to transfer information from HMRa while MATa cells switch using the silent cassette at HML alpha. Genetic analysis recently has defined a 700 bp recombination enhancer approximately 29 kb from the left end of chromosome III that is necessary for directionality. The chromatin structure of this region differs strikingly in a- and alpha-cells. Mat alpha2p organizes a 3.7 kb chromatin domain that opposes interaction of trans-acting proteins with the enhancer. In a-cells lacking the alpha2 repressor, two footprinted regions flank an approximately 100 bp section having a unique DNA structure. This structural signature probably reflects interactions of proteins that result in directional mating type switching.

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Journal Article | Research Support, U.S. Gov't, P.H.S.
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Weiss K, Simpson RT
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