Reference: Cone MC, et al. (1982) Utilization by Saccharomyces cerevisiae of 5'-methylthioadenosine as a source of both purine and methionine. J Bacteriol 151(1):510-5

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Abstract

Cells of the yeast Saccharomyces cerevisiae are normally impermeable to the purine nucleosides adenosine and 5'-deoxy-5'-methylthioadenosine (MTA), a product of polyamine biosynthesis. cordycepin-sensitive, adenosine-utilizing strains of S. cerevisiae were able to use MTA to fulfill an auxotrophic requirement for purine. Cordycepin-sensitive strains carrying a met5 mutation were also able to use MTA as a source of methionine. These MTA-utilizing strains of S. cerevisiae should be useful for metabolic studies of the fate of MTA.

Reference Type
Journal Article | Research Support, U.S. Gov't, P.H.S. | Comparative Study
Authors
Cone MC, Marchitto K, Zehfus B, Ferro AJ
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