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Reference: Querol CB, et al. (1994) Isolation and characterization of three mutants with increased sensitivity to photoactivated 3-carbethoxypsoralen in Saccharomyces cerevisiae. Curr Genet 25(5):407-11

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Abstract

The complementation and genetical analysis of yeast mutants sensitive to photoactivated 3-carbethoxypsoralen define three novel recessive mutant alleles pso5-1, pso6-1, and pso7-1. Their cross-sensitivity to UV254nm, radiomimetic mutagens, and to chemicals enhancing oxidative stress suggest that these mutants are either impaired in metabolic steps protecting from oxidative stress or in mechanisms of the repair of oxygen-dependent DNA lesions. None of the three novel mutant alleles block the induction of reverse mutation by photoactivated mono- and bi-functional psoralens, nitrogen mustards, or UV254nm.

Reference Type
Journal Article
Authors
Querol CB, Paesi-Toresan SO, Meira LB, Brendel M, Henriques JA
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