Reference: Juo ZS, et al. (1996) How proteins recognize the TATA box. J Mol Biol 261(2):239-54

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Abstract


The crystal structure of a complex of human TATA-binding protein with TATA-sequence DNA has been solved, complementing earlier TBP/DNA analyses from Saccharomyces cerevisiae and Arabidopsis thaliana. Special insight into TATA box specificity is provided by considering the TBP/DNA complex, not as a protein molecule with bound DNA, but as a DNA duplex with a particularly large minor groove ligand. This point of view provides explanations for: (1) why T.A base-pairs are required rather than C.G; (2) why an alternation of T and A bases is needed; (3) how TBP recognizes the upstream and downstream ends of the TATA box in order to bind properly; and (4) why the second half of the TATA box can be more variable than the first.

Reference Type
Journal Article | Research Support, U.S. Gov't, P.H.S.
Authors
Juo ZS, Chiu TK, Leiberman PM, Baikalov I, Berk AJ, Dickerson RE
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