The baker's yeast Saccharomyces cerevisiae can undergo pseudohyphal differentiation upon limited starvation for nitrogen. This differentiation is characterized by a hyperpolarized cell growth that gives rise to elongated cells. These elongated cells can form chains that penetrate an agar surface. The study of the grr1 mutant, affected in the degradation of the G1 cyclins, showed that the stabilization of Cln1 and Cln2 leads to a similar hyperpolarized cell growth. We suggest that G1 cyclin stability is a key element controlling cellular morphogenesis. Examination of G1 cyclin turnover during pseudohyphal growth strongly supports this hypothesis. Saccharomyces cerevisiae is thus an interesting model for studying the interconnections between cell cycle control and cellular differentiation.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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