Chromatin structure plays a crucial role in the regulation of eukaryotic gene transcription. Nucleosomes and higher orders of chromatin structure repress promiscuous gene expression by increasing its dependence on the function of activator proteins that regulate transcription in eukaryotic cells. Here we review several parameters governing the dynamic interactions between transcription factors and chromatin structures. These include functions of the core histones and their modification by acetylation, histone H1, HMG proteins, nucleosome positioning, DNA replication, cooperative nucleosome-binding by transcription factors, histone chaperones and nucleosome displacement, the SWI/SNF protein complex, and higher-order domains of chromatin structure. All of these impact on the interactions of transcription factors with chromatin templates. Experimental analysis of these parameters provides new insights into mechanisms of eukaryotic transcription regulation.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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