Two new mutants dbf3 and 4, are specifically defective in DNA synthesis. When synchronous cultures of dbf4 were transferred from the permissive to restrictive temperature before the start of the S phase, no DNA synthesis occurred. However when switched after the beginning of DNa replication, the cells completed that round of synthesis. Dbf4 therefore resembles cdc7, a mutant believed to be required for initiation of DNA synthesis, and indeed dbf4 acts at a point in the cell cycle close to cdd7, namely between cdd4 and the final requirement for protein synthesis before the S phase. Like dbf4, cultures of dbf3 transferred to restrictive conditions before the start of S showed little DNA synthesis. However a small burst did occur at a time roughly corresponding to when normal initiation would be expected. Cultures switched after this time completed the ongoing round of DNA synthesis.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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