Reference: Riis B, et al. (1990) Eukaryotic protein elongation factors. Trends Biochem Sci 15(11):420-4

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Abstract


In eukaryotes, peptide chain elongation is mediated by elongation factors EF-1 and EF-2. EF-1 is composed of a nucleotide-binding protein EF-1 alpha, and a nucleotide exchange protein complex, EF-1 beta gamma, while EF-2 catalyses the translocation of peptidyl-tRNA on the ribosome. Elongation factors are highly conserved among different species and may be involved in functions other than protein synthesis, such as organization of the mitotic apparatus, signal transduction, developmental regulation, ageing and transformation. Yeast contains a third factor, EF-3, whose structure and function is not yet well understood.

Reference Type
Comparative Study | Journal Article | Review
Authors
Riis B, Rattan SI, Clark BF, Merrick WC
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