Reference: Castrillo JI and Oliver SG (2011) Yeast systems biology: the challenge of eukaryotic complexity. Methods Mol Biol 759:3-28

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Abstract


In this chapter, we present an up-to-date view of the optimal characteristics of the yeast Saccharomyces cerevisiae as a model eukaryote for systems biology studies, with main molecular mechanisms, biological networks, and sub-cellular organization essentially conserved in all eukaryotes, derived from a complex common ancestor. The existence of advanced tools for molecular studies together with high-throughput experimental and computational methods, most of them being implemented and validated in yeast, with new ones being developed, is opening the way to the characterization of the core modular architecture and complex networks essential to all eukaryotes. Selected examples of the latest discoveries in eukaryote complexity and systems biology studies using yeast as a reference model and their applications in biotechnology and medicine are presented.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
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Castrillo JI, Oliver SG
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Gene Species Gene ID Strain background Direction Details Source Reference