Reference: Snider J and Houry WA (2008) AAA+ proteins: diversity in function, similarity in structure. Biochem Soc Trans 36(Pt 1):72-7

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Abstract


The AAA+ (ATPases associated with various cellular activities) superfamily of proteins represents a distinct lineage of the larger class of P-loop NTPases. Members of this superfamily use the power of nucleotide binding and hydrolysis to direct molecular remodelling events. All AAA+ proteins share a common core architecture, which, through various sequence and structural modifications, has been adapted for use in a remarkably diverse range of functions. The following mini-review provides a concise description of the major structural elements common to all AAA+ proteins in the context of their mechanistic roles. In addition, the evolutionary and functional diversity of this superfamily is described on the basis of recent classification studies.

Reference Type
Journal Article | Research Support, Non-U.S. Gov't | Review
Authors
Snider J, Houry WA
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