Because bacterial mechanosensitive channels have been cloned, purified, crystallized and subjected to a genetic, biochemical and physical scrutiny, they have become the current structural models of mechanosensation to atomic detail. The key observation, supported by recent mutagenesis studies, is that these channels receive stretch force directly through the lipid bilayer at the interface levels bearing highest tension. Indeed, simulations of mechanosensitive channels steered by strategically applied bilayer stretch forces show channel opening. Our understanding of the gating energetics and trajectory are continually being refined by the combination of approaches applied. In addition, new microbial mechanosensitive channels from the TRP family have been characterized in yeasts. Unified by fundamental biophysical principles of gating, mechanosensitive channels provide broad insight into protein-membrane interactions and the role of hydrophobic hydration in gating.
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| Evidence ID | Analyze ID | Gene/Complex | Systematic Name/Complex Accession | Qualifier | Gene Ontology Term ID | Gene Ontology Term | Aspect | Annotation Extension | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Phenotype | Experiment Type | Experiment Type Category | Mutant Information | Strain Background | Chemical | Details | Reference |
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| Evidence ID | Analyze ID | Gene | Gene Systematic Name | Disease Ontology Term | Disease Ontology Term ID | Qualifier | Evidence | Method | Source | Assigned On | Reference |
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| Evidence ID | Analyze ID | Regulator | Regulator Systematic Name | Target | Target Systematic Name | Direction | Regulation of | Happens During | Regulator Type | Direction | Regulation Of | Happens During | Method | Evidence | Strain Background | Reference |
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| Site | Modification | Modifier | Source | Reference |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Allele | Assay | Annotation | Action | Phenotype | SGA score | P-value | Source | Reference | Note |
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| Evidence ID | Analyze ID | Interactor | Interactor Systematic Name | Interactor | Interactor Systematic Name | Assay | Annotation | Action | Modification | Source | Reference | Note |
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| Complement ID | Locus ID | Gene | Species | Gene ID | Strain background | Direction | Details | Source | Reference |
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| Evidence ID | Analyze ID | Dataset | Description | Keywords | Number of Conditions | Reference |
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